API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing
نویسندگان
چکیده
منابع مشابه
Modelling and control of combined cooling and antisolvent crystallization processes
Available online xxxx
متن کاملAdaptive Concentration Control of Cooling and Antisolvent Crystallization with Laser Backscattering Measurement
This paper presents a thorough simulation and experimental evaluation of the concentration control approach for batch and semibatch crystallization. The sensitivity of concentration feedback control is assessed in the case of various disturbances that result in excessive nucleation events. The enhanced robustness of the concentration control is demonstrated against the widely used direct operat...
متن کاملPurification of Erythromycin by Antisolvent Crystallization or Azeotropic Evaporative Crystallization
Crystallization plays an important role in separation and purification of the antibiotics. And it is also an indispensable step in preparation of pharmaceuticals with biological activities and specific crystal form. As the last step in purification, crystallization determines the puri‐ ty, crystal habit, granularity and its distribution as well as pharmacologic effect, biologic ac‐ tivity and p...
متن کاملMathematical Modeling and Design of Novel Semi-continuous and Continuous Crystallizations
Crystallization is an important separation technology used for the purification of products during their final stages of manufacturing. Novel semi-continuous and continuous crystallization process designs are receiving increasing attention in pharmaceutical industry due to significant advantages in terms of process, operation and costs. This dissertation aims to develop mathematical models for ...
متن کاملIn situ pressure crystallization: an alternative to crystallization by cooling
Acta Crystallographica Section A: Foundations and Advances publishes articles reporting fundamental advances in all areas of crystallography in the broadest sense. This includes metacrystals such as photonic or phononic crystals, i.e. structures on the mesoor macroscale that can be studied with crystallographic methods. The central themes are, on the one hand, experimental and theoretical studi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organic Process Research & Development
سال: 2021
ISSN: 1083-6160,1520-586X
DOI: 10.1021/acs.oprd.0c00345